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research 877 Loss of UBE2N in keratinocytes leads to skin inflammation and immune infiltration through IRAK1/4-mediated processes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that deleting Ube2n in adult mouse skin leads to inflammation and other skin changes, and identifies IRAK1/4 as potential treatment targets for inflammatory skin disorders.

Transgenic Mice Overexpressing CD109 in the Epidermis Display Decreased Inflammation and Granulation Tissue and Improved Collagen Architecture During Wound Healing

research Transgenic mice overexpressing CD109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing

22 citations , February 2013 in “Wound Repair and Regeneration”

In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.

research Is female-pattern hair loss an autoimmune-like disorder? Unveiling the “silent” inflammation

January 2026 in “Journal of Investigative Dermatology”

Female-pattern hair loss may involve an autoimmune-like process, suggesting new treatment options.

research The Association of Lacrimal Gland Inflammation with Alopecia Areata

2 citations , October 2014 in “Orbit”

This study observed that lacrimal gland inflammation and alopecia areata, both autoimmune conditions, can occur together in patients.

research Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus

31 citations , January 2009 in “Autoimmunity Reviews”

This study suggests that damage to stem cells in the bulge region of hair follicles may contribute to scarring in chronic cutaneous lupus erythematosus.

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Community Join

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community Hair Loss & Lipids: Why you have sebderm, folliculitis, LPP, inflammation, etc...

131 upvotes 1 year ago

Excess sebum rich in cholesterol and triglycerides can lead to hair loss through inflammation, with treatments like Ciclopirox shampoo, Benzoyl Peroxide shampoo, and Clindamycin gel recommended for managing conditions like seborrheic dermatitis and folliculitis. Pioglitazone is suggested for Lichen Planopilaris, while Omega-3s and reducing processed foods may improve sebum quality, though genetic factors play a significant role.

community Scalp Inflammation Beyond Psoriasis: A Hidden Player in Hair Thinning

in Technology 54 upvotes 4 months ago

Scalp inflammation may contribute to hair thinning, with treatments like ketoconazole shampoo potentially helping by reducing inflammation. Some users report that DHT blockers and other treatments like finasteride, minoxidil, and RU58841 can alleviate symptoms associated with inflammation.

community Hair Loss Inflammation Prevention Stack

48 upvotes 1 year ago

The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

community 9 years of hair loss process and 27 months of treatment. What's going on?

40 upvotes 1 year ago

The user experienced hair loss diagnosed as chronic Telogen Effluvium and male pattern baldness, treated with finasteride and minoxidil, later switching to dutasteride due to side effects but with limited success. The user plans to return to finasteride due to side effects from dutasteride, while others suggest maintaining consistent treatment and considering additional options like oral minoxidil and lifestyle changes.

community Treating my DUPA via controlling inflammation

5 upvotes 2 years ago

The user has DUPA and suspects autoimmune activity as a cause. They have tried various treatments including finasteride, minoxidil, dutasteride, pyrilutamide, estrogel, hydrocortisone, and clobetasol, and are now seeking a long-term immunosuppressant.

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Learn

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learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

learn Hydrocortisone

a synthetic cortisol used for anti-inflammatory effects

Is hydrocortisone effective for stopping inflammation that blocks hair growth? Sources describe hydrocortisone as a short-course treatment for scalp inflammation such as seborrhoeic dermatitis or eczema, and no verified trial tests it as a hair-regrowth treatment; the corticosteroids used for alopecia areata are the potent prescription ones, and prolonged use of any topical steroid on the scalp risks skin thinning.

learn Thymosin Beta 4

learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Omega 3

Did you know omega-3 can lower scalp inflammation that leads to sudden hair loss? Omega-3 can reduce scalp inflammation, potentially preventing sudden hair loss.
Does omega-3 help with scalp inflammation or irritation linked to conditions like dandruff or alopecia? Omega-3 may help reduce scalp inflammation linked to dandruff and alopecia.

learn Ginkgo biloba

Can ginkgo biloba reduce scalp inflammation that contributes to hair loss? Ginkgo biloba may help reduce scalp inflammation, potentially benefiting hair loss.

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