Epigenetic Control of Adult Stem Cell Function

    July 2016 in “ Nature Reviews Molecular Cell Biology ”
    Alexandra Avgustinova, Salvador Aznar Benitah
    Studysummary This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.
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    Research cited in this study 12

    1. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    2. Divergent Roles of HDAC1 and HDAC2 in the Regulation of Epidermal Development and Tumorigenesis The EMBO Journal · 2013
    3. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    4. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013
    5. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012
    6. Distinct Stem Cells Contribute to Mammary Gland Development and Maintenance Nature · 2011
    7. P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis The Journal of Cell Biology · 2011
    8. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    9. EZH1 and EZH2 Co-Govern Histone H3K27 Trimethylation and Are Essential for Hair Follicle Homeostasis and Wound Repair Genes & Development · 2011
    10. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    11. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    12. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003