An Ovol2-Zeb1 Transcriptional Circuit Regulates Epithelial Directional Migration and Proliferation

November 2018 in “ EMBO Reports ”

Daniel Haensel, Peng Sun, Adam L. MacLean, Xianghui Ma, Yuan Zhou, Marc P. Stemmler, Simone Brabletz, Geert Berx, Maksim V. Plikus, Qing Nie, Thomas Brabletz, Xing Dai

Ovol2 Zeb1 epithelial cell migration epithelial cell proliferation wound healing hair follicle regeneration epidermal cell migration epidermal cell proliferation matrix cell proliferation matrix cell differentiation epithelial-to-mesenchymal transition EMT epidermal keratinocytes bulge hair follicle stem cells Bu-HFSCs post-mitotic cell cycle arrest

Studysummary This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.

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