Low-Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System With a Focus on Pericardial Effusions

    September 2024 in “ Journal of Cosmetic Dermatology ”
    Aditya K. Gupta, Mary A. Bamimore, Husam Abdel‐Qadir … Mesbah Talukder
    Studysummary This study examined the FDA Adverse Event Reporting System database and found significant associations between low-dose oral minoxidil use and adverse events like pericardial effusion, highlighting the need for caution and recommending the use of the lowest effective dose until more safety data are available.
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    Research cited in this study 11

    1. Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review Skin appendage disorders · 2023
    2. There Is a Positive Dose-Dependent Association Between Low-Dose Oral Minoxidil and Its Efficacy for Androgenetic Alopecia: Findings From a Systematic Review With Meta-Regression Analyses Skin appendage disorders · 2022
    3. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    4. Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose 2021
    5. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    6. Comment on 'Low Dose Oral Minoxidil for Treating Alopecia: A 3-Year North American Retrospective Case Series': Adding Further Evidence About Side Effects Journal of The American Academy of Dermatology · 2021
    7. Adverse Effects of Low-Dose Oral Minoxidil for Androgenetic Alopecia in 435 Patients Journal of The American Academy of Dermatology · 2020
    8. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    9. Low-Dose Oral Minoxidil as Treatment for Non-Scarring Alopecia: A Systematic Review International Journal of Dermatology · 2020
    10. Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris Journal of The American Academy of Dermatology · 2020
    11. Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability and the Five C’s of Oral Therapy Dermatologic Therapy · 2018

    Related research 2

    1. Low-Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System With a Focus on Pericardial Effusions Journal of Cosmetic Dermatology · 2024
    2. Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024 medRxiv (Cold Spring Harbor Laboratory) · 2024