Gynostemma Pentaphyllum Hydrodistillate and Damulin B Prevent UVB-Induced Photoaging In Vitro and In Vivo via ROS Suppression and Restoration of MAPK/AP-1 and TGF-β/Smad Signaling

January 2026 in “ Molecular Nutrition & Food Research ”

SeoYeon Lee, Lochana Kovale, Jihyun Lee, Changhyun Lee, Hyeon‐A. Song, Kyung‐tae Lee, Wonchae Choe, Insug Kang, Sung Soo Kim, Joohun Ha

Gynostemma pentaphyllum Damulin B UVB-induced skin damage reactive oxygen species MAPK/AP-1 signaling TGF-β/Smad signaling extracellular matrix hyaluronic acid metabolism collagen degradation epidermal hyperplasia GPHD ROS ECM

Studysummary This study found that Gynostemma pentaphyllum hydrodistillate and Damulin B exert significant anti-photoaging effects in UVB-irradiated models by reducing oxidative stress, improving ECM integrity, and enhancing skin hydration and elasticity.

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research Gynostemma Pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth via the Wnt/Beta-Catenin Pathway

March 2024 in “Nutrients”

This study found that Gynostemma pentaphyllum leaf hydrodistillate (GPHD) promoted hair growth in mice similarly to minoxidil and upregulated growth factor expression via the AKT/β-catenin signaling pathway, with damulin B identified as an active component contributing to these effects.