Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS

December 2022 in “ Journal of Clinical Medicine ”

Elisabeth Reiser, Julia Lanbach, Bettina Böttcher, Bettina Toth

metformin GLP-1RA GLP-1-agonists phytotherapeutic extracts antiandrogen medication polycystic ovary syndrome PCOS GLP-1 receptor agonists herbal medicines

Studysummary This review suggests that, among non-hormonal treatments for menstrual irregularities in adolescents with PCOS, metformin is the most effective and cost-efficient option, particularly in overweight adolescent girls.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses non-hormonal treatment options for regulating the menstrual cycle in adolescents with polycystic ovary syndrome (PCOS). It mentions that medications targeting glucose metabolism and weight control may be beneficial in improving menstrual frequency. Metformin shows overall benefit, while GLP-1RA and ROS have conflicting data. The document emphasizes the need for more studies in adolescents with PCOS and mentions the potential of GLP-1-agonists and phytotherapeutic extracts as promising treatment options. It also discusses the role of antiandrogen medication in improving menstrual frequency and the importance of effective contraception. The document concludes that combined therapy options and herbal medicines may have beneficial effects, but more research is needed.

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research Criteria for Diagnosis of Polycystic Ovary Syndrome During Adolescence: Literature Review

42 citations , August 2022 in “Diagnostics”

This review examines existing evidence on PCOS diagnostic criteria for adolescents and underscores the need for accurate definitions, while highlighting limited research, especially regarding adolescents at risk of PCOS.

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In this research, animal tests confirmed that chromium supplementation effectively maintains glycaemic and insulinaemic balance and affects certain hormone levels, but the authors note that clinical evidence for chromium's benefits in PCOS treatment remains sparse and inconsistent, warranting further exploration.

A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

research A 12-Week Treatment with the Long-Acting Glucagon-Like Peptide 1 Receptor Agonist Liraglutide Leads to Significant Weight Loss in a Subset of Obese Women with Newly Diagnosed Polycystic Ovary Syndrome

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research Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study

23 citations , February 2014 in “Journal of Pediatric and Adolescent Gynecology”

This study found that a low-dose intermittent finasteride regimen significantly reduced hirsutism scores in adolescent girls with PCOS or idiopathic hirsutism, with similar efficacy but potentially safer and less expensive than continuous administration.

Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

research Short-Term Combined Treatment With Liraglutide and Metformin Leads to Significant Weight Loss in Obese Women With Polycystic Ovary Syndrome and Previous Poor Response to Metformin

116 citations , December 2013 in “European journal of endocrinology”

This study found that combining liraglutide with metformin led to greater weight loss and waist circumference reduction than either treatment alone in obese women with PCOS resistant to metformin monotherapy.

Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

research Improved Efficacy of Low-Dose Spironolactone and Metformin Combination Than Either Drug Alone in the Management of Women With Polycystic Ovary Syndrome: A Six-Month, Open-Label Randomized Study

75 citations , July 2013 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that combining low-dose spironolactone with metformin provided greater clinical benefits and improved treatment compliance in women with PCOS compared to either drug alone.

research Intermittent Low-Dose Finasteride Is as Effective as Daily Administration for the Treatment of Hirsute Women

29 citations , September 2004 in “Fertility and Sterility”

This study found that an intermittent low-dose regimen of finasteride (2.5 mg every 3 days) effectively reduced hirsutism scores in women with idiopathic hirsutism or polycystic ovary syndrome, with fewer side effects than continuous daily administration.