Non polycystic ovary syndrome–related endocrine disorders associated with hirsutism

    Kürşad Ünlühizarcı, Gregory Kaltsas, Fahrettin Keleştimur
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    TLDR Hirsutism can be caused by various conditions besides PCOS, and it's important to treat the underlying issue and manage symptoms with medication and cosmetic approaches.
    The document reviews the causes and treatments of hirsutism not related to polycystic ovary syndrome (PCOS), emphasizing that while PCOS is the most common cause, other conditions like nonclassical adrenal hyperplasia, idiopathic hirsutism, HAIR-AN syndrome, and various endocrine disorders can also lead to hirsutism. It discusses the role of androgens in hair growth, the importance of diagnosing and treating underlying conditions, and the potential cardiovascular risks associated with hyperandrogenism. Treatments include pharmacological options such as antiandrogens, oral contraceptives, gonadotrophin-releasing hormone agonists, insulin sensitizers, and cosmetic measures. The document notes that low-dose finasteride is as effective as high-dose therapy for hirsutism, and spironolactone can be combined with finasteride for improved outcomes. It also mentions the importance of using effective contraception with finasteride due to its teratogenic potential. The document stresses the need for individualized treatment plans and the importance of recognizing hirsutism as a sign of potentially serious conditions. It does not provide specific numbers of study participants, so the strength of the evidence cannot be assessed.
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