Inflammatory Memory-Activated Biomimetic Nanovesicles Regulate Neutrophil Plasticity and Metabolic Reprogramming for Rapid Diabetic Wound Healing via Targeting miR-193a-5p/TLR4/JNK/P38 MAPK Pathways

The study investigates the use of inflammatory memory-activated biomimetic nanovesicles (LEM) derived from epithelial stem cells to enhance diabetic wound healing. These nanovesicles promote the transition of neutrophils to an anti-inflammatory N2 phenotype, reduce inflammation, and accelerate wound regeneration by targeting the miR-193a-5p/TLR4/JNK/P38 MAPK pathways. In diabetic mouse models, LEM treatment resulted in faster wound closure and improved skin regeneration. The study highlights the potential of LEM in regulating neutrophil plasticity and metabolic reprogramming, offering a promising therapeutic approach for diabetic wound management without the need for cell implantation. The research involved a sample size of 3 per group.