Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm

March 2021 in “ Reproduction ”

Michala Rosa Birch, Steen Dissing, Niels E. Skakkebæk, Anders Rehfeld

finasteride CatSper channel Ca2+ signaling PGE1 progesterone acrosome reaction sperm viability sperm penetration prostaglandin signaling Propecia

Studysummary This study found that finasteride may affect Ca 2+ signalling in human sperm by interacting with the PGE 1 -binding site, but its impact on fertilization requires further investigation.

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