Molecular Mechanisms of Ectodermal Dysplasia Syndromes

June 2004 in “ Työväentutkimus Vuosikirja ”

Johanna Laurikkala

ectodermal dysplasia hypohidrotic ectodermal dysplasia EEC syndrome epithelial-mesenchymal interactions FGFs Hh gene family Notch receptors TGF superfamily Wnt family tumor necrosis factors TNF receptors

Studysummary This article reviews the roles of several signaling pathways and molecules, including FGFs, Hh, Notch, TGF, and Wnt, in the development of teeth and hair follicles, but reports no new findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA

250 citations , November 2003 in “The Journal of Cell Biology”

This study found that BMP receptor IA is crucial for hair progenitor cell differentiation in mice, and its sequential inhibition and activation are necessary to generate a functioning hair shaft.

research Identification of a Secreted BMP Antagonist, Ectodin, Integrating BMP, FGF, and SHH Signals from the Tooth Enamel Knot

243 citations , October 2003 in “Developmental biology”

This study identified ectodin as a novel BMP inhibitor that modulates BMP signaling in ectodermal development by interacting with SHH and FGF pathways.

research Stimulation of Ectodermal Organ Development by Ectodysplasin-A1

249 citations , May 2003 in “Developmental Biology”

Ectodysplasin-A1 is crucial for developing hair, teeth, and glands.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations , January 2003 in “The FASEB Journal”

This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.

research Overexpression of Smad7 Results in Severe Pathological Alterations in Multiple Epithelial Tissues

111 citations , June 2002 in “The EMBO Journal”

This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

research Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors

297 citations , January 2002 in “Development”

In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

211 citations , October 2001 in “The FASEB Journal”

This study found that the BMP antagonist noggin induces hair growth in postnatal skin by neutralizing BMP4's inhibitory activity, potentially mediated by changes in Shh expression.

research Edar/Eda Interactions Regulate Enamel Knot Formation in Tooth Morphogenesis

208 citations , November 2000 in “Development”

This study found that while Eda and Edar proteins interact in vitro, their roles in dental development differ, with downless mutant mice showing distinct tooth defects compared to tabby mutants.

research Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers

109 citations , June 2000 in “Development”

This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.

Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

research Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

62 citations , January 2000 in “Developmental dynamics”

This study found that Notch-related genes, including Notch1 and Notch2, and their ligands and regulators, have distinct patterns of expression during mouse hair vibrissa follicle development and the adult hair cycle.

research Regulation of a Hair Follicle Keratin Intermediate Filament Gene Promoter

39 citations , December 1998 in “Journal of Cell Science”

This study found that the LEF-1 binding site acts as an enhancer element for the wool keratin intermediate filament gene promoter in hair follicle cortex, with specificity regulated by additional factors.

research Splitting Hairs: Molecular Mechanisms of Hair and Feather Development

158 citations , November 1998 in “Cell”

β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.

research Expression and Function of FGFs-4, -8, and -9 Suggest Functional Redundancy and Repetitive Use as Epithelial Signals During Tooth Morphogenesis

252 citations , March 1998 in “Developmental dynamics”

This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.

research Mutation of a Type II Keratin Gene (K6a) in Pachyonychia Congenita

232 citations , July 1995 in “Nature Genetics”

research Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination

150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

This study suggests that mNotch expression plays a significant role in hair follicle differentiation and cell fate selection within the follicle during development.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.

research A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin

156 citations , January 1989 in “Genes & Development”

This study found that keratin K14 expression occurs early in epidermal cell differentiation, while a hair-specific keratin is expressed later in hair matrix cells, suggesting developmental divergence between the two cell types.