Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

March 2023

Wen-Yen Huang, Shih‐Fan Lai, Hsien‐Yi Chiu, Michael Chang, Maksim V. Plikus, Chih‐Chieh Chan, You‐Tzung Chen, Po‐Nien Tsao, Tsung‐Lin Yang, Mei‐Hsuan Lee, Peter Chi, Sung‐Jan Lin

hair follicles genotoxicity chemotherapy radiotherapy hair loss low-dose ionizing radiation keratin 5+ basal hair bulb progenitors high-dose ionizing radiation outer root sheath cells stem cell-like properties WNT signaling p53 progenitor cell proliferation alopecia transit-amplifying cell-derived progenitors quiescent bulge stem cells chemo radiation therapy low-dose radiation high-dose radiation stem cells progenitor cells transit-amplifying cells bulge stem cells

Studysummary In this study, various cellular responses and signaling pathways were examined in hair follicles after exposure to ionizing radiation, including the effects of Wnt3a treatment, with findings noted in apoptosis, DNA damage, and differentiation processes.

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research Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

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Results are not reported in this study, which investigated the effects of radiation on hair follicles and evaluated various cellular responses and signaling pathways, particularly focusing on WNT signaling and the impact of Wnt3a treatment.

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors to Prevent Hair Loss from Chemotherapy or Radiation Therapy

research Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

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This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.

Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

research Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

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This study suggests that targeting the activation of transit-amplifying cell-derived progenitor cells may help prevent hair loss from chemotherapy and radiotherapy by promoting hair follicle regeneration.

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