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GlossaryStem Cell Quiescence

state where stem cells remain inactive to preserve function

Stem cell quiescence, also known as stem cell dormancy, refers to a state in which stem cells remain inactive or non-dividing. This state helps protect the stem cells from exhaustion and damage, ensuring they can be activated when needed for tissue repair or regeneration. Quiescent stem cells are crucial for maintaining long-term tissue health and preventing premature aging or diseases like cancer.

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Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling

research Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling

April 2023 in “Journal of Investigative Dermatology”

Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.

research Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells

414 citations, August 2005 in “Nature”

Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.

research KLF4 Maintains Hair Follicle Stem Cell Quiescence

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

KLF4 is important for keeping hair follicle stem cells inactive.

research Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

March 2023

Boosting certain cell signals can prevent hair loss from chemotherapy and radiation.

research Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy

March 2023

Boosting certain cell signals can prevent hair loss from chemotherapy and radiation.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.