Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy
March 2023
hair follicles genotoxicity chemotherapy radiotherapy hair loss low-dose ionizing radiation keratin 5+ basal hair bulb progenitors high-dose ionizing radiation outer root sheath cells stem cell-like properties WNT signaling p53 progenitor cell proliferation alopecia chemo radiation therapy low-dose radiation keratin 5+ cells high-dose radiation stem cell properties WNT pathway p53 protein cell proliferation
TLDR Boosting certain cell signals can prevent hair loss from chemotherapy and radiation.
The study investigates how hair follicles (HFs) respond to genotoxicity-induced injury from chemotherapy and radiotherapy, which often leads to hair loss. It was found that after low-dose ionizing radiation (IR), keratin 5+ basal hair bulb progenitors are activated to regenerate hair follicles, while high-dose IR causes outer root sheath cells to acquire stem cell-like properties to fuel HF regeneration. The research highlights that augmenting WNT signaling can counteract the suppressive effects of p53, enhancing progenitor cell proliferation and preventing hair loss. This suggests that targeting transit-amplifying cell-derived progenitors, rather than quiescent bulge stem cells, could be a viable strategy to prevent chemotherapy and radiotherapy-induced alopecia.
