Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis

October 2000 in “ Nature ”

Mei Li, Arup Kumar Indra, Xavier Warot, Jacques Brocard, Nadia Messaddeq, Shigeaki Kato, Daniel Metzger, Pierre Chambon, Mei Li, Arup Kumar Indra, Xavier Warot, Jacques Brocard, Nadia Messaddeq, Shigeaki Kato, Daniel Metzger, Pierre Chambon

RXRα keratinocytes hair cycling RXR/VDR heterodimers epidermal keratinocytes skin physiology

Studysummary This study found that RXRα plays a critical role in hair cycling and keratinocyte functions in mice, likely through its interaction with VDR in epidermal cells.

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