Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes During Skin Aging

    June 2019 in “ Journal of Investigative Dermatology ”
    Mohammed I. Ahmed, Maximilian E. Pickup, Alexander Rimmer, Majid Alam, Andrei N. Mardaryev, Krzysztof Poterlowicz, Natalia V. Botchkareva, Vladimir A Botchkarev
    Studysummary The researchers reported that miR-21 expression increases with age in both human and mouse skin and may contribute to skin aging by targeting the chromatin remodeler SATB1 in keratinocytes. Our plain-language summary of this paper — not a Tressless recommendation.
    The study identified microRNA-21 (miR-21) as a contributor to skin aging by negatively regulating the chromatin remodeler SATB1 in keratinocytes. It showed that miR-21 expression increased in aged skin of both mice and humans, while SATB1 expression decreased. This inverse relationship suggested that miR-21 targets SATB1, leading to reduced expression of keratinocyte differentiation-related genes, which may contribute to cellular senescence and increased susceptibility to age-related skin conditions. The findings provided insights into the molecular mechanisms of skin aging and suggested potential therapeutic targets for modulating skin aging through miR-21 activity.
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