TLDR miR-21 increases skin aging by reducing SATB1, affecting skin cell function.
The study identified microRNA-21 (miR-21) as a contributor to skin aging by negatively regulating the chromatin remodeler SATB1 in keratinocytes. It showed that miR-21 expression increased in aged skin of both mice and humans, while SATB1 expression decreased. This inverse relationship suggested that miR-21 targets SATB1, leading to reduced expression of keratinocyte differentiation-related genes, which may contribute to cellular senescence and increased susceptibility to age-related skin conditions. The findings provided insights into the molecular mechanisms of skin aging and suggested potential therapeutic targets for modulating skin aging through miR-21 activity.
22 citations
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April 2017 in “Journal of Investigative Dermatology” Non-coding RNAs are crucial for skin development and health.
103 citations
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November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
1 citations
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September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” MicroRNA-148a is crucial for maintaining healthy skin and hair growth by affecting stem cell functions.
12 citations
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May 2015 in “Molecular Medicine Reports” Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.
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3 citations
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April 2022 in “Biomolecules” Higher miR-34a levels and the A variant of the MIR-34A gene are linked to increased risk and severity of alopecia areata.
8 citations
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March 2015 in “Molecular Medicine Reports” Hair dye ingredient PPD causes cell death and aging in human hair cells by altering microRNA levels.
