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Did you mean Chromatin Remodeling?

GlossaryChromatin Remodeling

restructuring of DNA-protein complexes to regulate gene expression

Chromatin remodeling refers to the dynamic modification of the structure of chromatin, which is the complex of DNA and proteins in the nucleus of a cell. This process involves the repositioning or restructuring of nucleosomes (the basic units of chromatin) to either expose or hide specific DNA regions, thereby regulating gene expression. For a layperson, it's like rearranging books on a shelf to make certain ones easier to read, while for a professional, it involves understanding the specific molecular mechanisms and enzymes, such as ATP-dependent chromatin remodelers, that facilitate these changes.

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research Linking Morphogen and Chromatin in the Hair Follicle

April 2013 in “Developmental Cell”

Brg1 is crucial for keeping hair follicle stem cells and repairing skin, working with the Sonic Hedgehog pathway to promote hair growth.

research The ATP-Dependent Chromatin Remodeler BRG1 Controls Epidermal Keratinocyte Migration During Human Cutaneous Wound Healing

April 2019 in “Journal of Investigative Dermatology”

BRG1 is essential for skin cells to move and heal wounds properly.

Chromatin Remodeler Lymphoid-Specific Helicase (Lsh) Is a Critical Determinant Controlling Postnatal Epidermal Growth, Differentiation, and Response to Injury

research Chromatin Remodeler Lymphoid-Specific Helicase (Lsh) Is a Critical Determinant Controlling Postnatal Epidermal Growth, Differentiation, and Response to Injury

April 2016 in “Journal of Investigative Dermatology”

Lymphoid-specific helicase (Lsh) is crucial for skin growth, change, and healing after injury.

research Integration of Biochemical and Mechanical Signals at the Nuclear Periphery: Impacts on Skin Development and Disease

January 2018 in “Stem cell biology and regenerative medicine”

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

research The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates

6 citations, July 2023 in “Nature cell biology”

SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.

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community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.