Safety and Efficacy of Mesotherapy with Placenta Polypeptide Injection for Moderate-to-Severe Sensitive Skin: A Multicenter, Randomized, Controlled Trial

    January 2026 in “ Clinical Cosmetic and Investigational Dermatology ”
    Chang Shu, Xi Zhang, Xuefeng Han … Qingping Sun
    Studysummary This study found that mesotherapy with placenta polypeptide injection significantly reduced skin inflammation and improved aesthetic outcomes in adults with moderate-to-severe sensitive skin, without increasing adverse events compared to controls.
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    Research cited in this study 7

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    2. In Vitro Biological Activity and In Vivo Human Study of Porcine Placenta Extract Loaded Nanovesicle Formulations for Skin and Hair Rejuvenation Pharmaceutics · 2022
    3. A Novel Approach for Skin Regeneration by a Potent Bioactive Placental-Loaded Microneedle Patch: Comparative Study of Deer, Goat, and Porcine Placentas Pharmaceutics · 2022
    4. Human Placental Extract: A Potential Therapeutic in Treating Osteoarthritis Annals of Translational Medicine · 2021
    5. Mesococktails and Mesoproducts in Aesthetic Dermatology Dermatologic therapy · 2020
    6. Sensitive Skin Journal of the European Academy of Dermatology and Venereology · 2016
    7. Human Placental Extract Exerts Hair Growth-Promoting Effects Through the GSK-3β Signaling Pathway in Human Dermal Papilla Cells International Journal of Molecular Medicine · 2015