Sorafenib Stimulates Human Skin Type Mast Cell Degranulation and Maturation

August 2017 in “ Journal of dermatological science ”

Yukari Mizukami, Koji Sugawara, Yukimi Kira, Daisuke Tsuruta

sorafenib mast cells degranulation PI3K signaling stem cell factor SCF skin reactions

Studysummary This study found that sorafenib increased mast cell number and degranulation in skin, suggesting PI3K signaling and SCF production may underlie its adverse cutaneous reactions.

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