Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles

    January 1991 in “Journal of Investigative Dermatology
    Thomas P. Dooley, Cynthia J. Walker, Sharon J. Hirshey, Charles N. Falany, A. R. Diani
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    TLDR Minoxidil works in liver and outer hair root sheath for hair growth.
    This study from 1991 aimed to determine the site(s) of action of minoxidil, a drug used to stimulate hair growth. The researchers found that minoxidil sulfotransferase (MST) is present in the liver and the outer root sheath of anagen hair follicles in rats. This suggests that the lower outer root sheath of the hair follicle may serve as a site for the sulfation of topically applied minoxidil. The study provides insight into the localization of MST in hair follicles and its potential role in hair growth.
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