A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

    June 2026 in “ Cosmetics ”
    Ralf Jäger, Martin Purpura, Sebastian T. Balcombe … Alejandro Pérez‐Fernández
    Studysummary In this study, a polyphenol and biotin supplement improved skin roughness and significantly reduced hair shedding, but did not demonstrate clear superiority over placebo in overall skin outcomes.
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    Research cited in this study 8

    1. The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest-Posttest Study Health Science Reports · 2025
    2. Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration 2024
    3. The Formulation and In-Vitro Evaluation of WS Biotin, a Novel Encapsulated Form of D-Biotin with Improved Water Solubility for Hair and Skin Treatment Applications International Journal of Cosmetic Science · 2023
    4. Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss JAMA dermatology · 2022
    5. Skin, Hair, and Beyond: The Impact of Menopause Climacteric · 2022
    6. Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth in a Randomized Clinical Trial Journal of Medicinal Food · 2017
    7. A Review of the Use of Biotin for Hair Loss Skin appendage disorders · 2017
    8. Prevalence of Hair Shedding Among Women Dermatologic Therapy · 2016