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research A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

June 2026 in “Cosmetics”

In this study, a polyphenol and biotin supplement improved skin roughness and significantly reduced hair shedding, but did not demonstrate clear superiority over placebo in overall skin outcomes.

research The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects

5 citations , April 2013 in “Journal of Cosmetic and Laser Therapy”

This study found that Argireline significantly reduced the depth of periorbital wrinkles in Chinese subjects and improved skin morphology in aged mice.

research The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands

11 citations , April 2021 in “Journal of Clinical Medicine”

This study found that long-term use of a home-use LED device for neck skin rejuvenation significantly improved wrinkle appearance and skin biophysical parameters without affecting thyroid function or morphology after 16 weeks of daily use.

research Skin morphology of the mutant hairless USP mouse

11 citations , January 2005 in “Brazilian Journal of Medical and Biological Research”

This study found no qualitative skin differences during development between mutant hairless USP mice and BALB/c mice, except for enlarged cysts in the hairless strain.

research Aging of the Human Lip: Current Knowledge and Clinical Implications

1 citations , July 2025 in “Journal of Cosmetic Dermatology”

This review found that lip aging differs significantly from facial aging and suggests focusing on distinct anti-aging strategies for lips, considering gender differences and unique physiological characteristics.

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community Blaming Finasteride doesn't help you solve anything: dry eyes

51 upvotes 1 year ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.

community Deep wrinkles in last year since starting oral minoxidil? Anyone else?

8 upvotes 2 years ago

A user noticed deeper facial wrinkles since starting oral minoxidil in February 2023 and is concerned about its effects on collagen production. Other factors include past accutane use, high stress, poor sleep, and COVID-19.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

community If minox causes facial wrinkles, then I should mix my Min/Fin for 1 dose daily, not 2?

4 upvotes 3 years ago

Minoxidil may cause facial aging, possibly due to alcohol and propylene glycol (PG) content. The user plans to reduce Minoxidil and Finasteride to one daily dose to minimize these effects.

community How common are dark eye circles / wrinkles with Minoxidil?

in Minoxidil 4 upvotes 9 years ago

The user is concerned about potential side effects of Minoxidil, specifically dark eye circles and wrinkles, and is seeking others' experiences. They have been using finasteride and recently started Nizoral, but are hesitant to begin Minoxidil due to these concerns.

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