Lasers for Other Specific Dermatologic Disorders

April 2019

Leyre Falto‐Aizpurua, Mohammad‐Ali Yazdani Abyaneh, Harleen Arora, Robert Griffith, Ali Rajabi‐Estarabadi, Keyvan Nouri

alopecia areata immunotherapy squaric acid dibutylester diphenylcyclopropenone narrowband-ultraviolet B phototherapy xenon-chloride excimer laser pulsed dye laser phototherapy AA SADBE DPCP NBUVB excimer laser PDL

TLDR Lasers and light therapy are effective for treating skin conditions like hair loss, vitiligo, psoriasis, and molluscum contagiosum.

The chapter reviewed the use of laser and light therapy for various pediatric dermatologic disorders, including alopecia areata (AA), vitiligo, psoriasis, molluscum contagiosum (MC), morphea, atopic dermatitis, lichen planus, and pityriasis lichenoides chronica. For AA, immunotherapy with agents like squaric acid dibutylester and diphenylcyclopropenone was commonly used. Narrowband-ultraviolet B phototherapy was a first-line treatment for generalized vitiligo, while the xenon-chloride excimer laser was an alternative for localized vitiligo. Psoriasis treatment depended on disease severity. The pulsed dye laser was noted as a safe and effective treatment for MC. Phototherapy was also considered an adjuvant or alternative treatment for atopic dermatitis.

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research A Review of Monochromatic Light Devices for the Treatment of Alopecia Areata

28 citations , December 2017 in “Lasers in Medical Science”

Monochromatic light devices, especially the 308-nm excimer laser, are promising for treating alopecia areata but more research is needed.

research Low-Level Laser Therapy for Treatment of Hair Loss

165 citations , August 2013 in “Lasers in Surgery and Medicine”

Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.

research Common Pediatric Skin Conditions with Protracted Courses

9 citations , April 2013 in “Dermatologic clinics”

Some new treatments for children's skin conditions are effective, but risks must be weighed.

research Oxidative Stress and Autoimmune Skin Disease

73 citations , January 2013 in “European journal of dermatology/EJD. European journal of dermatology”

Antioxidants may help fight oxidative stress linked to autoimmune skin diseases.

research Effects of the Lexington LaserComb on Hair Regrowth in the C3H/HeJ Mouse Model of Alopecia Areata

81 citations , July 2011 in “Lasers in Medical Science”

The Lexington LaserComb helped regrow hair in mice with a condition similar to human hair loss.

research Histopathology of Alopecia Areata, Acute and Chronic: Why Is It Important to the Clinician?

43 citations , May 2011 in “Dermatologic Therapy”

Recognizing the different stages of alopecia areata is crucial for accurate diagnosis and treatment.

research Alopecia Areata: An Autoimmune Disease Causing Hair Loss

16 citations , May 2011 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Alopecia Areata is an autoimmune disease causing hair loss in patches, often starting before age 20, and while some cases recover on their own, treatments include topical corticosteroids, minoxidil, and promising new methods like IL-31 antibodies and 308-nm Excimer laser therapy.

research Alopecia Areata: Clinical Review and Treatment Approaches

50 citations , March 2000 in “American Journal of Clinical Dermatology”

Alopecia Areata has no guaranteed treatment for hair regrowth, but options like corticosteroids and minoxidil are used, with future research focusing on genetic and immune therapies.