Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes

    November 2021 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Hideyuki Kosumi, Mika Watanabe, Satoru Shinkuma … Ken Natsuga
    Studysummary This study found that inhibiting Wnt/β-catenin signaling disrupted hemidesmosome organization in keratinocytes, suggesting potential therapeutic targets for HD-defective diseases like epidermolysis bullosa.
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    Research cited in this study 7

    1. Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development EMBO reports · 2021
    2. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    3. Life Before and Beyond Blistering: The Role of Collagen XVII in Epidermal Physiology Experimental Dermatology · 2018
    4. Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis eLife · 2017
    5. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    6. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    7. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002

    Related research 1

    1. Stabilization of Hemidesmosomal Proteins: A Possible Key Contributor to Wnt/β-Catenin Pathway Action in the Skin Journal of Investigative Dermatology · 2021