Bioengineered Microneedles and Nanomedicine as Therapeutic Platform for Tissue Regeneration

August 2025 in “ Journal of Nanobiotechnology ”

Y T Mao, Shihui Xu, Xiaozhou Shi, Yanjia Jin, Zihan Pan, Hao Tian, Guoping Li, Xuerui Chen, Hongdong Wang, Yongtao Wang, Junjie Xiao

bioengineered microneedles nanomedicine tissue regeneration chronic wounds degenerative diseases polymers metals drug delivery dissolving microneedles hollow microneedles controlled drug delivery targeted drug release responsive drug release skin regeneration biomaterials biofabrication

Studysummary This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Silicate-Based Therapy for Inflammatory Dilated Cardiomyopathy by Inhibiting the Vicious Cycle of Immune Inflammation via FOXO Signaling

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14 citations , December 2024 in “Pharmaceutics”

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research Diagnostic, Therapeutic, And Theranostic Multifunctional Microneedles

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57 citations , January 2024 in “ACS Nano”

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research Design and Fabrication of Customizable Microneedles Enabled by 3D Printing for Biomedical Applications

81 citations , October 2023 in “Bioactive Materials”

This review highlights the promising potential of 3D printing for creating microneedles with precise customization and improved performance compared to traditional micromolding, emphasizing applications in personalized medical devices and advancements in biomedical fields.

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research Dissolving Microneedle Patch Integrated With Microspheres For Long-Acting Hair Regrowth Therapy

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This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.

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research Advanced Nanocarrier- and Microneedle-Based Transdermal Drug Delivery Strategies for Skin Diseases Treatment

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This review discusses advancements in the use of microneedle arrays and nanoparticles for transdermal delivery of therapeutics, noting challenges in overcoming the skin barrier and summarizing recent clinical trial achievements in areas like cancer therapy and gene therapy.