Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

    Ilysa Diamond, Timothy Owolabi, Melissa Marco … Adam B. Glick
    Studysummary This study found that the tetracycline-regulated transcription system effectively controls conditional gene expression in the mouse epidermis, allowing suppression and activation of specific genes with doxycycline.
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    Research cited in this study 2

    1. Conversion of C57Bl/6 Mice from a Tumor Promotion-Resistant to a Sensitive Phenotype by Enhanced Ornithine Decarboxylase Expression Molecular Carcinogenesis · 1999
    2. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991

    Related research 3

    1. Analysis of Proliferation, Apoptosis, and Keratin Expression in Cultured Normal and Immortalized Human Buccal Keratinocytes European Journal Of Oral Sciences · 2003
    2. Keratin and Skin Disorders Cell biology international · 1996
    3. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989