Keratinocyte Cytokine Networks Associated With Human Melanocytic Nevus Development
September 2018
in “
Journal of Investigative Dermatology
”
keratinocyte cytokine networks melanocytic nevi MAPK pathway KITLG HGF FGF2 EDN1 melanocyte activation pigmentation genetic variations hair follicle growth basal cell carcinoma MTAP/CDKN2A PLA2G6 IRF4 nevus count genetic polymorphisms keratinocyte networks moles MAPK stem cell factor hepatocyte growth factor fibroblast growth factor 2 endothelin 1 mole count hair growth skin cancer CDKN2A mole susceptibility
TLDR Keratinocyte cytokines and genetic variations influence the development of moles and skin pigmentation.
The study investigated the role of keratinocyte cytokine networks in the development of human melanocytic nevi, traditionally linked to MAPK pathway mutations. It found that keratinocyte cytokines like KITLG, HGF, FGF2, and EDN1 were associated with melanocyte activation and pigmentation, influenced by genetic variations. The research identified five classes of keratinocyte genes impacting melanocyte activity, linking nevus development with hair follicle growth and basal cell carcinoma. Key genes such as MTAP/CDKN2A, PLA2G6, IRF4, and KITLG were associated with nevus count, with KITLG being a major cytokine correlated with melanocyte markers. The study suggested that genetic polymorphisms in these pathways might contribute to nevus susceptibility, highlighting the complexity of keratinocyte-melanocyte interactions.
