Comparison of Two In Vitro Models for the Analysis of Follicular Penetration and Its Prevention by Barrier Emulsions

February 2009 in “ European journal of pharmaceutics and biopharmaceutics ”

Jürgen Lademann, Alexa Patzelt, Heike Richter, Sabine Schanzer, Wolfram Sterry, Alexander Filbry, K. Bohnsack, Frank Rippke, Martina C. Meinke

follicular penetration barrier emulsions excised human skin porcine ear skin

Studysummary This study found that porcine ear skin is more suitable than excised human skin for investigating the efficacy of barrier emulsions in preventing pollen allergen penetration due to its lack of tissue contraction.

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research The Role of Hair Follicles in the Percutaneous Absorption of Caffeine

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research Comparison of Stratum Corneum Penetration and Localization of a Lipophilic Model Drug Applied in an O/W Microemulsion and an Amphiphilic Cream

132 citations , April 2007 in “European journal of pharmaceutics and biopharmaceutics”

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research Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

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In this study, caffeine applied in a shampoo penetrated hair follicles faster and more effectively than through the skin surface within the first 20 minutes.

research Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties

27 citations , January 2006 in “Colloids and Surfaces B: Biointerfaces”

This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.

research Follicular Targeting: A Promising Tool in Selective Dermatotherapy

109 citations , November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This article discusses the role of hair follicles in enhancing topical drug delivery and explores strategies for targeting these areas to improve treatment outcomes for skin diseases, but reports no new research results.

research Transfollicular Drug Delivery: Is It a Reality?

141 citations , November 2005 in “International journal of pharmaceutics”

This review examines the role of hair follicles and sebaceous glands in percutaneous drug delivery but does not report new clinical results; it calls for further exploration of follicle-targeting therapies.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.