Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

January 2017 in “ Skin Pharmacology and Physiology ”

Luís A. C. Roque, Inês S Dias, Nuno Cruz, Ana Cristina Silva Rebelo, Amílcar Roberto, Maria José Calhorda, Catarina Pinto Reis

finasteride nanoparticles PLGA nanoparticles topical formulations lotion shampoo solution alopecia Propecia

Studysummary This study found that polymeric nanoparticles may effectively deliver finasteride topically to hair follicles, potentially improving alopecia treatment with fewer side effects than oral forms.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on karger.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

58 citations , December 2012 in “Aaps Pharmscitech”

This study suggests that finasteride-loaded liquid crystalline nanoparticles could be a viable alternative to oral administration for treating androgenetic alopecia due to their controlled release and skin permeation properties.

research Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia

41 citations , October 2011 in “Journal of Dermatology”

This study observed that long-term use of finasteride in Japanese men with androgenetic alopecia was associated with progressive hair regrowth in 87.1% of participants without significant safety concerns.

research Preparation of Novel Polymeric Microspheres for Controlled Release of Finasteride

37 citations , May 2007 in “International Journal of Pharmaceutics”

The study concluded that poly(propylene carbonate maleate) microspheres effectively encapsulated finasteride, achieving a biphasic release with prolonged drug release over 5-6 weeks in vitro.

research Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation

56 citations , January 2007 in “Pharmaceutical Development and Technology”

This study found that finasteride-loaded liposomal formulations achieved significantly higher skin permeation and deposition compared to conventional gels and solutions, suggesting potential for effective topical application.

research Finasteride in the Treatment of Androgenetic Alopecia

62 citations , April 2004 in “Expert Opinion on Pharmacotherapy”

This article reviews the use of finasteride for treating male pattern hair loss, highlighting its mechanism of action in reducing DHT and noting its safety profile with some common adverse effects.

research The Value of Hair Cosmetics and Pharmaceuticals

59 citations , January 2001 in “Dermatology”

This article discusses the role of dermatologists in advising patients on hair cosmetics and pharmaceuticals, highlighting the development of cosmeceuticals and the need for accurate information on health hazards associated with hair care products, but reports no new results.