Treatment of Concomitant Alopecia Areata and Systemic Lupus Erythematosus with Ivarmacitinib: A Case Report and Literature Review

    September 2026 in “ Frontiers in Medicine ”
    Wenjie Li, Zisheng Zhang, Ruoxin Huang … Yongliang Chu
    Studysummary This case report highlights a woman with alopecia areata and systemic lupus erythematosus who showed significant improvement in hair loss after treatment with ivarmacitinib, suggesting its potential benefit for overlapping autoimmune alopecia.
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    Research cited in this study 20

    1. Alopecia Areata Nature Reviews Disease Primers · 2025
    2. Ivarmacitinib for the Treatment of Adults with Severe Alopecia Areata: Results from a Phase 3 Trial Journal of the American Academy of Dermatology · 2025
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    4. Immune-Mediated Disorders in Patients With Alopecia Areata: Systematic Review and Meta-Analysis International Journal of Dermatology · 2025
    5. Treatment of Discoid Lupus Erythematosus Scarring Alopecia with Deucravacitinib: A Case Report SAGE Open Medical Case Reports · 2025
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    7. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
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    15. Efficacy of JAK 1/2 Inhibition in the Treatment of Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Annals of the rheumatic diseases · 2020
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    17. Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus American Journal of Clinical Dermatology · 2018
    18. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    19. Non-Scarring Patchy Alopecia in Patients with Systemic Lupus Erythematosus Differs from That of Alopecia Areata Lupus · 2013
    20. Involvement of Scalp and Nails in Lupus Erythematosus Lupus · 2010