Refractory Alopecia in Lupus Treated with Tofacitinib: A Case-Based Review

    May 2023 in “ Clinical Rheumatology ”
    Rajdeep Sarkar, Prakashini MV, Naga Hinduja … Sakir Ahmed
    Studysummary This case report highlights a 33-year-old female with systemic lupus erythematosus and refractory alopecia who experienced significant hair regrowth after treatment with tofacitinib, maintained even after glucocorticoid tapering over two years.
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    Research cited in this study 11

    1. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    2. Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib Frontiers in Immunology · 2021
    3. Efficacy of JAK 1/2 Inhibition in the Treatment of Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Annals of the rheumatic diseases · 2020
    4. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    5. Review of Quality of Life Studies in Women with Alopecia International Journal of Women's Dermatology · 2018
    6. Recovery of Nail Dystrophy: Potential New Therapeutic Indication of Tofacitinib Clinical rheumatology · 2017
    7. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    8. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    9. Non-Scarring Patchy Alopecia in Patients with Systemic Lupus Erythematosus Differs from That of Alopecia Areata Lupus · 2013
    10. Severe Diffuse Non-Scarring Hair Loss in Systemic Lupus Erythematosus: Clinical and Histopathological Analysis of Four Cases Journal of the European Academy of Dermatology and Venereology · 2011
    11. Cross-Sectional Study of Hair Loss Patterns in 122 Korean Systemic Lupus Erythematosus Patients: A Frequent Finding of Non-Scarring Patch Alopecia The Journal of Dermatology · 2007

    Related research 2

    1. Resistant Alopecia Areata Treated with Tofacitinib International Journal of Trichology · 2022
    2. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018