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$Oral Tofacitinib Monotherapy in Korean Patients with Refractory Moderate-to-Severe Alopecia Areata: A Case Series$

research Oral tofacitinib monotherapy in Korean patients with refractory moderate-to-severe alopecia areata: A case series

44 citations , October 2017 in “Journal of the American Academy of Dermatology”

In this study, tofacitinib monotherapy was effective in achieving hair regrowth in over half of Korean patients with moderate-to-severe and refractory alopecia areata, though treatment discontinuation typically led to hair loss recurrence.

research Refractory alopecia in lupus treated with tofacitinib — a case-based review

5 citations , May 2023 in “Clinical Rheumatology”

This case report highlights a 33-year-old female with systemic lupus erythematosus and refractory alopecia who experienced significant hair regrowth after treatment with tofacitinib, maintained even after glucocorticoid tapering over two years.

research Refractory alopecia areata with single hairs imitating frontal fibrosing alopecia: a prospective observational study

2 citations , December 2023 in “International Journal of Dermatology”

In this study, researchers identified a unique variant of alopecia areata characterized by an increase in telogen hair follicles and minimal inflammation present in the microenvironment.

$Refractory Alopecia Universalis Associated with Dermatomyositis Successfully Treated with Tofacitinib$

research Refractory alopecia universalis associated with dermatomyositis successfully treated with tofacitinib

2 citations , March 2022 in “Modern Rheumatology Case Reports”

In this study, a case of a patient with dermatomyositis and alopecia universalis showed successful treatment with tofacitinib, suggesting potential responsiveness to janus kinase inhibitors.

research New Modalities in the Treatment of Refractory Alopecia Areata

1 citations , May 2017 in “InTech eBooks”

This review summarizes current treatments for recalcitrant alopecia areata and recent therapeutic developments targeting specific immunological pathways, reporting no new clinical results.

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Community Join

5 / 23 results

community Stop the fear mongering of oral minoxidil its one of the best treatments available in 2020. It does not cause heart lesions or adverse cardiac effects like people claim. I am maintaining with just oral minoxidil with retrograde alopecia and diffuse thinning all over nw3 hairline

78 upvotes 5 years ago

Oral minoxidil is considered a safe and effective treatment for hair loss at low dosages, with minimal cardiac risks. Users report positive results, though some experience side effects like increased heart rate and skin changes, and consulting a doctor is advised.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Why do some doctors recommend starting with minoxidil before finasteride? (treatment philosophy question)

in Research/Science 20 upvotes 4 months ago

Doctors recommend starting with minoxidil for hair loss due to its lower risk of side effects compared to finasteride. Some believe finasteride should be used early to address the root cause, but a conservative approach is preferred by medical professionals.

community A New Hair Loss Drug Could Cure Balding and Reverse Graying

367 upvotes 10 months ago

ABS-201, a prolactin receptor blocker, shows promise in reversing hair loss and graying, with early success in macaques. Current treatments like finasteride, minoxidil, and RU58841 are still widely used, but new options like PP405 are eagerly anticipated.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

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Learn

6 / 801 results

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

Finasteride for alopecia: the definitive guide to using it correctly. Finasteride 1 mg daily blocks DHT and, in trials, slowed hair loss in most men over 6 to 12 months, though some men do not respond and the benefit lasts only while the drug is taken. It is prescription-only and carries a pregnancy contraindication.

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

Baricitinib: How did a drug for arthritis end up helping people regrow hair from alopecia areata? Baricitinib helps regrow hair by targeting the autoimmune response in alopecia areata.

learn Alfatradiol

Alfatradiol: Can it help if my hair loss is linked to DHT? The one randomised trial of topical alfatradiol — in 103 women — found hair thickness and density essentially unchanged after six months, while minoxidil improved both; its authors credited alfatradiol with slowing hair loss rather than regrowing hair. Laboratory work supports a local effect on follicular DHT, but no controlled trial in men appears to have been published.

learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

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