Intralesional Methotrexate Comparable to Triamcinolone Acetonide and Superior to Vitamin D3 in Treating Alopecia Areata

    July 2025 in “ International Journal of Trichology ”
    Karem Taha Khalil, Asmaa Mohamed Alrefaei, Yossra Mahmoud Mohamed Mostafa
    Studysummary This study found that intralesional methotrexate and triamcinolone acetonide were significantly more effective than Vitamin D3 for hair regrowth in patients with alopecia areata.
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    Research cited in this study 8

    1. Intralesional Vitamin D3 in Treatment of Alopecia Areata: A Randomized Controlled Clinical Trial Journal of Cosmetic Dermatology · 2022
    2. A Retrospective Comparative Study of Two Concentrations of Intralesional Triamcinolone Acetonide in the Treatment of Patchy Alopecia Areata on the Scalp Clinical Cosmetic and Investigational Dermatology · 2020
    3. Trichoscopy of Alopecia Areata: An Update The Journal of Dermatology · 2018
    4. Correlation of Vitamin D and Vitamin D Receptor Expression in Patients with Alopecia Areata: A Clinical Paradigm International Journal of Dermatology · 2017
    5. The Role of Vitamin D in Non-Scarring Alopecia International Journal of Molecular Sciences · 2017
    6. Best Dilution of the Best Corticosteroid for Intralesional Injection in the Treatment of Localized Alopecia Areata in Adults Journal of dermatological treatment · 2017
    7. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012
    8. Systemic Treatment for Alopecia Areata Dermatologic therapy · 2011