Intralesional Methotrexate in Patchy Alopecia Areata: Trichoscopic Evaluation and Effect on Lesional Tumor Necrosis Factor Alpha

    May 2026 in “ Journal of the Egyptian Womenʼs Dermatologic Society ”
    Ahmed A. Afify, Samar A. Salem, Walid A. Ahmed, Rodaina M. Farag
    Studysummary In this prospective study, 15 patients with patchy alopecia areata treated with intralesional methotrexate every two weeks showed a significant improvement in hair regrowth and reduction in lesion severity, with changes linked to decreased tissue levels of TNF-α.
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    Research cited in this study 12

    1. Evaluation of Serum Levels of IL-6, IL-10, and TNF-a in Alopecia Areata Patients: A Systematic Review and Meta-Analysis Biomedical Research and Therapy · 2021
    2. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    3. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    4. Treatment of Alopecia Areata: An Australian Expert Consensus Statement Australasian journal of dermatology · 2018
    5. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    6. Methotrexate for the Treatment of Pediatric Alopecia Areata Journal of dermatological treatment · 2017
    7. Low-Dose Systemic Methotrexate Therapy for Recalcitrant Alopecia Areata Annals of Dermatology · 2017
    8. SALT II: A New Take on the Severity of Alopecia Tool for Determining Percentage Scalp Hair Loss Journal of The American Academy of Dermatology · 2016
    9. Efficacy and Safety of Methotrexate in Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2014
    10. Utility of Dermoscopy in Alopecia Areata Indian Journal of Dermatology/Indian journal of dermatology · 2011
    11. Coudability Hairs: A Revisited Sign of Alopecia Areata Assessed by Trichoscopy Clinical and experimental dermatology · 2010
    12. The Role of Scalp Dermoscopy in the Diagnosis of Alopecia Areata Incognita Journal of The American Academy of Dermatology · 2008