Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation
September 2007
in “
The Journal of Steroid Biochemistry and Molecular Biology
”
TLDR Glucocorticoid receptors help regulate genes important for skin health and hair growth.
The study identified 173 genes regulated by the glucocorticoid receptor (GR) in mouse skin using a transgenic mouse model overexpressing GR in epidermal basal cells and hair follicles. Key findings included the identification of hair keratin (krt) and keratin-associated protein (krtap) genes, as well as hox genes, as being regulated by GR, suggesting a role in hair follicle morphogenesis. The study also found that GR repressed genes related to cell growth, such as fosb and c-fos, highlighting its antiproliferative effects. These findings provided insights into the role of glucocorticoids in skin physiology and potential implications for hair disorders.
