Hair Follicle Physiology And Mechanisms Of Hair Disorders

October 2022 in “ Hair Transplantation ”

hair follicles hair disorders hair fiber caliber hair density hair growth cycle anagen phase telogen phase genetics hormones inflammation follicle size follicle regeneration

Studysummary This chapter reviews the basic physiology and causal mechanisms of hair follicle disorders, but it reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The chapter reviewed the basic physiology of hair follicles and the mechanisms behind hair disorders, which involve changes in hair fiber caliber, density, and the hair growth cycle's anagen and telogen phases. It highlighted that genetics, environment, hormones, or inflammation could trigger these disorders, with varying contributions depending on the specific diagnosis. Treatments aimed to normalize the hair growth cycle, modulate follicle size, and potentially regenerate follicles to maintain hair density. The chapter provided examples of hair disorders to illustrate these concepts.

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research The Changing Landscape of Alopecia Areata: The Translational Landscape

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research Prognosis and Management of Congenital Hair Shaft Disorders with Fragility—Part I

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research Telogen Effluvium: A Review

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research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

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This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

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research Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

29 citations , October 2011 in “British Journal of Dermatology”

This study found that four microRNAs, which were significantly upregulated in balding hair follicle papilla cells, could play a role in the development of male pattern baldness.

research Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice

173 citations , September 2011 in “Journal of Investigative Dermatology”

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

research Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata

66 citations , July 2010 in “Journal of Proteome Research”

This study suggests that an immune response to trichohyalin and keratin 16 may contribute to the pathogenesis of alopecia areata.

research APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex

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research The Hair Follicle as a Dynamic Mini-Organ

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This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research The Hair Cycle

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research The Biology of Hair Follicles

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This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.