TLDR The hair coat disorder in Schipperkes is similar to Alopecia X and involves increased androstenedione levels and hair cycle arrest.
The study described and characterized a hair coat disorder in schipperkes, presenting as bilaterally symmetrical alopecia with no systemic clinical signs, resembling Alopecia X. It involved 11 schipperkes (3 healthy and 8 affected) and included comprehensive blood tests, hormone analyses, and skin biopsies. Results showed normal CBC, serum chemistry, UA, T4, fT4ed, TSH, and post-ACTH cortisol levels. However, increased concentrations of androstenedione, estradiol, progesterone, and 17-hydroxyprogesterone were observed in both healthy and affected dogs, particularly post-ACTH stimulation. Histopathology indicated hair cycle arrest in affected dogs, supporting the clinical and histological resemblance to Alopecia X.
The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.
34 citations
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July 2006 in “Clinics in dermatology”
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