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    A Pilot Randomized Controlled Trial Comparing the Efficacy and Safety of Oral Tofacitinib Versus Methotrexate in Moderate-To-Severe Alopecia Areata

    June 2026 in “ Indian Dermatology Online Journal ”
    Mude Hemalatha, Tarun Narang, Muthu Sendhil Kumaran … Sunil Dogra
    Studysummary In this pilot study, both tofacitinib and methotrexate improved alopecia areata outcomes, but tofacitinib showed greater efficacy in achieving significant SALT score improvement after 6 months, although the difference was not statistically significant.
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    Research cited in this study 14

    1. Clinical Profile and Predictors of Relapse in Patients with Alopecia Areata: A Follow-Up Study Indian Journal of Dermatology · 2024
    2. Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-Analysis Acta dermato-venereologica · 2023
    3. Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the European Academy of Dermatology and Venereology · 2019
    4. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    5. Is Methotrexate an Effective and Safe Treatment for Maintaining Hair Regrowth in People with Alopecia Totalis? A Critically Appraised Topic British journal of dermatology/British journal of dermatology, Supplement · 2018
    6. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    7. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    8. Management of Alopecia Areata: Updates and Algorithmic Approach Journal of dermatology · 2017
    9. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    10. Efficacy and Safety of Methotrexate in Alopecia Areata Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia · 2014
    11. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012
    12. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    13. Alopecia in the United States: Outpatient Utilization and Common Prescribing Patterns Journal of the American Academy of Dermatology · 2007
    14. Alkaline Phosphatase in Alopecia Areata Archives of Dermatology · 1957