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GlossaryTransaminitis

elevated liver enzymes indicating potential liver inflammation or damage

Transaminitis refers to an elevated level of liver enzymes, specifically alanine transaminase (ALT) and aspartate transaminase (AST), in the blood. This condition often indicates liver inflammation or damage, which can be caused by various factors such as infections, medications, alcohol use, or autoimmune diseases. While it is not a disease itself, transaminitis is a sign that further investigation is needed to determine the underlying cause.

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Trends in the Presence or Absence of Transaminitis and/or Leukopenia in Pediatric Patients Treated with Methotrexate for Inflammatory Skin Disease

research Trends in the Presence or Absence of Transaminitis and/or Leukopenia in Pediatric Patients Treated with Methotrexate for Inflammatory Skin Disease

February 2013 in “Journal of The American Academy of Dermatology”

Most children with skin inflammation taking methotrexate had lab abnormalities, but liver issues often improved without changing the medication dose.

research Valproate-Associated Transaminitis and Rhabdomyolysis

2 citations, April 2023 in “Curēus”

Valproic acid can cause muscle damage and liver issues, which improve after stopping the drug.

research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis

41 citations, December 2015 in “JAMA Dermatology”

Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.

research Kava-Induced Acute Cutaneous Toxicity: An Increasingly Recognized Characteristic Clinicohistologic Pattern

2 citations, November 2018 in “JAAD case reports”

Drinking kava tea can cause a skin reaction with red, swollen bumps, which may improve with steroids.

research A Randomized Controlled Trial Comparing the Efficacy and Safety of Oral Tofacitinib vs. Methotrexate in Moderate-to-Severe Alopecia Areata

June 2025 in “British Journal of Dermatology”

Tofacitinib was more effective than methotrexate for treating alopecia areata.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 11 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.