Tofacitinib in the Recalcitrant Cases of Alopecia Areata: A Pilot Study

June 2025 in “ International Journal of Science and Research (IJSR) ”

N Swathi, H C Mangala, x Sugareddy

tofacitinib alopecia areata Severity of Alopecia Areata score SALT score

A pilot study investigated the efficacy and safety of oral tofacitinib in treating recalcitrant cases of alopecia areata in 20 patients aged 10-50 years over 6 months. The study found a significant decrease in the Severity of Alopecia Areata (SALT) score, with an average improvement of 27% in 19 patients, indicating effective hair regrowth. Side effects were minimal, occurring in only 3 patients. Despite the small sample size and short duration, the study concluded that a 5mg BD dose of tofacitinib is effective for alopecia areata, though proper lab monitoring is necessary for patient safety.

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6 / 12 results

community 22F. Should I even bother getting a biopsy? Is there any point?

8 upvotes 9 years ago

A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

community IGE Hair Loss and Miniaturization

in Chat 3 upvotes 10 months ago

A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

in Progress Pictures 290 upvotes 1 year ago

The conversation discusses the severe shedding caused by Minoxidil, with users sharing their experiences and outcomes. Some report eventual regrowth, while others see no improvement or worsening hair loss.

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