This study investigates the activity of alkaline phosphatase (A.P.) in different stages of alopecia areata and alopecia totalis. Alkaline phosphatase is an enzyme involved in various metabolic processes, but its specific role in skin metabolism is unclear. Previous reports indicated decreased A.P. activity in hair papillae during early alopecia areata. The study involved 10 scalp biopsies from patients with varying stages of hair loss and regrowth, including areas treated with hydrocortisone injections. The research aims to further understand A.P. activity in these conditions.
73 citations
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July 1956 in “Journal of Investigative Dermatology” Adult human skin can grow new fine hair follicles after a deep exfoliation treatment.
521 citations
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January 1954 in “Physiological Reviews” Hair growth is cyclic and influenced mainly by local factors.
1 citations
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January 2022 in “Dermatology Reports” Many people with hair loss, especially those with telogen effluvium and alopecia areata, often have a sensitive scalp.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
September 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)” 
109 citations
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May 2011 in “Dermatologic Therapy” Alopecia areata is a type of hair loss that can lead to complete baldness, often associated with other autoimmune conditions, and half of the cases may see hair return within a year.
