Alkaline Phosphatase in Alopecia Areata

The study investigates the role of alkaline phosphatase (A.P.) in alopecia areata and alopecia totalis by analyzing 10 scalp biopsies from patients at different stages of hair loss and regrowth. Previous reports indicated a decrease in A.P. activity in hair papillae during early alopecia areata. This research aims to further understand A.P. activity in these conditions, including areas treated with hydrocortisone injections. The precise role of A.P. in cutaneous metabolic processes remains unclear, but its activity is linked to various biochemical processes and may influence hair loss and regrowth.