Finasteride as a Model for Personalized Medicine

    October 2017 in “ Journal of Mind and Medical Sciences ”
    Ion G. Motofei, David L. Rowland, Ioana Paunica, Octavian C. Tănăsescu, Petrisor Banu, Stana Paunica
    TLDR Finasteride treatment should be personalized to individual mental profiles.
    The paper discussed the controversial side effects of Finasteride, noting that while some studies reported minor and temporary adverse effects, others indicated persistent issues known as post-Finasteride syndrome. The authors proposed that these inconsistent findings could be due to differences in study designs, particularly whether patients were informed about potential side effects beforehand. They also suggested that individual differences in brain structure and neuromodulation could lead to varied mental impairments and responses to the drug. The conclusion emphasized the need for a personalized medical approach, tailoring therapeutic strategies to individual mental profiles, which could enhance understanding in fields like psychology, psychiatry, and sexuality.
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      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      Dutasteride is less commonly prescribed for hair loss because it is not FDA-approved for this purpose, unlike finasteride, which is more accessible and preferred due to fewer side effects. Dutasteride may be more effective in reducing DHT but has a longer half-life and potentially more significant side effects.

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