Influence of Extracellular Matrix on the Proliferation and Adhesion Properties of Stem Cells Derived from Different Sources

June 2017

Anna Bajek, Dorota Porowińska, Krzysztof Roszkowski

extracellular matrix ECM hair follicle stem cells fibronectin laminin collagen IV poly-D-lysine stem cell niche

TLDR Extracellular matrix components affect stem cell growth and adhesion differently based on their source.

The study investigated the impact of various extracellular matrix (ECM) components on the adhesion and proliferation of stem cells from bone marrow, adipose tissue, and hair follicles. It was found that ECM components such as fibronectin, laminin, collagen IV, and poly-D-lysine influenced stem cells differently depending on their source. Bone marrow and adipose-derived mesenchymal stem cells generally maintained their proliferation on these ECM components, except for laminin, which reduced proliferation. In contrast, hair follicle stem cells showed different responses, highlighting the ECM's role in the cellular niche and its potential necessity for recreating the stem cell niche in vitro. This research underscored the biocompatibility of ECM-modified surfaces for culturing specific stem cell types.

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