Comparing the Efficacy of Combined Intralesional Triamcinolone Acetonide With Topical Calcipotriol Versus Intralesional Triamcinolone Acetonide Monotherapy in Scalp and Beard Alopecia Areata: Results From a Randomized Single-Blinded Clinical Trial

January 2025 in “ Journal of Cutaneous Medicine and Surgery ”

Thoyyib Parammal Karat, Anupama Bains, Abhishek Bhardwaj, Saurabh Singh, Anil Budania, Suman Patra, Bandhala Rajan M

triamcinolone acetonide calcipotriol alopecia areata intralesional therapy topical treatment hair regrowth terminal hair density scalp patches beard patches atrophy steroid injection vitamin D analog AA hair loss skin irritation

TLDR The combination treatment was more effective for scalp hair regrowth but caused more irritation.

The study investigated the efficacy of combining intralesional triamcinolone acetonide with topical calcipotriol versus using intralesional triamcinolone acetonide alone in treating scalp and beard alopecia areata. Conducted as a randomized single-blinded clinical trial, the research included a sample size of 100 participants. Results indicated that the combination therapy was significantly more effective in promoting hair regrowth compared to the monotherapy. The findings suggest that adding topical calcipotriol to intralesional triamcinolone acetonide treatment could enhance therapeutic outcomes for patients with alopecia areata.

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Research cited in this study

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research Response to 'Vitamin D Status in Scarring and Nonscarring Alopecia'

May 2022 in “Journal of the American Academy of Dermatology”

The document suggests using a topical Vitamin D treatment for hair loss rather than oral supplements and calls for more research.

research Identification of Novel Step-Up Regimen of Intralesional Triamcinolone Acetonide in Scalp Alopecia Areata Based on a Double-Blind Randomized Controlled Trial

3 citations, November 2020 in “Dermatologic Therapy”

Start with 2.5 mg/mL triamcinolone acetonide for scalp alopecia areata and increase if needed.

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

research Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study

10 citations, April 2020 in “Dermatology and therapy”

Calcipotriol works almost as well as clobetasol for mild to moderate alopecia areata with fewer side effects.

research Topical Calcipotriol vs Narrowband Ultraviolet B in Treatment of Alopecia Areata: A Randomized-Controlled Trial

9 citations, June 2019 in “Archives of Dermatological Research”

Both topical calcipotriol and narrowband UVB improved alopecia, but combining them didn't enhance the effect on hair loss severity, despite higher vitamin D3 levels.

research Evaluation of Platelet-Rich Plasma vs Intralesional Steroid in Treatment of Alopecia Areata

19 citations, May 2019 in “Journal of Cosmetic Dermatology”

Platelet-rich plasma is a safe and effective treatment for hair loss, with fewer relapses than steroid treatment.

research Comparative Study of Efficacy of Topical Mometasone with Calcipotriol Versus Mometasone Alone in the Treatment of Alopecia Areata

9 citations, January 2019 in “International Journal of Trichology”

Combining calcipotriol with mometasone is more effective for treating alopecia areata than using mometasone alone.

research Alopecia Areata: Treatment Options and Efficacy

182 citations, December 2017 in “Journal of the American Academy of Dermatology”

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

research Best Dilution of the Best Corticosteroid for Intralesional Injection in the Treatment of Localized Alopecia Areata in Adults

22 citations, May 2017 in “Journal of dermatological treatment”

BD 1/4 dilution is the best for treating localized alopecia areata in adults.

research Efficacy and Safety of Topical Calcipotriol in Management of Alopecia Areata: A Pilot Study

39 citations, January 2017 in “Dermatologic Therapy”

Topical calcipotriol may help treat alopecia areata, especially in those with low vitamin D.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations, January 2016 in “Cellular physiology and biochemistry”

Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.

research Alopecia Areata: An Update

67 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

The document concludes that alopecia areata is an autoimmune disease without a definitive cure, but treatments like corticosteroids are commonly used.

research Dermoscopic Evaluation of Therapeutic Response to an Intralesional Corticosteroid in the Treatment of Alopecia Areata

35 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Intralesional triamcinolone acetonide is effective for treating patchy hair loss, and dermoscopy helps detect treatment response and side effects early.

research Intralesional Treatment of Alopecia Areata with Triamcinolone Acetonide by Jet Injector

100 citations, July 2006 in “British Journal of Dermatology”

Triamcinolone acetonide injections help hair regrow quickly in mild alopecia but not in severe cases.

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Comparative Study Between Topical Steroid Alone Versus Combined Fractional Erbium:YAG Laser With Topical Steroid In Treatment Of Alopecia Areata

research Comparative Study Between Topical Steroid Alone Versus Combined Fractional Erbium:YAG Laser With Topical Steroid In Treatment Of Alopecia Areata

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The combination of laser and topical steroids is more effective for treating alopecia areata than topical steroids alone.