Comparative Efficacy of Topical Calcipotriol, Intralesional Autologous Platelet-Rich Plasma Injection, and Combined Topical Calcipotriol with Intralesional Autologous Platelet-Rich Plasma Injection on Patients with Alopecia Areata

    September 2025 in “ Journal of Skin and Stem Cell ”
    Mohammed Abu El-Hamd, Moustafa Adam El-Taieb, Faten Othman Ahmed, Ali Mohamed Younis, Mohamed Amer Ahmed Abdellatif, Eisa M. Hegazy
    Image of study
    TLDR The combination of calcipotriol and PRP is the most effective treatment for alopecia areata.
    This study evaluated the effectiveness of topical calcipotriol, intralesional autologous platelet-rich plasma (PRP) injection, and their combination in treating alopecia areata (AA) in 78 patients. Results showed significant reductions in the Severity of Alopecia Tool (SALT) scores across all treatment groups, with the combination treatment showing the greatest improvement (18.98 points), followed by the PRP group (6.87 points), and the calcipotriol group (3.73 points). The study concluded that all treatments were effective, with the combination therapy being the most effective.
    Discuss this study in the Community →

    Research cited in this study

    23 / 23 results

    Related Community Posts Join

    6 / 13 results

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  5 upvotes 3 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  45 upvotes 7 months ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  408 upvotes 8 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community Second shed and more abnormalities

      in Treatment  1 upvotes 1 year ago
      The user has been using oral finasteride for 15 months and oral minoxidil for 6 months, and developed alopecia areata, for which a dermatologist prescribed calcipotriol/betamethasone. The treatment is helping, but the user is experiencing another shedding phase and is concerned about the effects of the steroid cream and the cause of hair loss.

    Similar Research

    5 / 623 results