Comparative Efficacy of Topical Calcipotriol, Intralesional Autologous Platelet-Rich Plasma Injection, and Combined Topical Calcipotriol with Intralesional Autologous Platelet-Rich Plasma Injection on Patients with Alopecia Areata

    September 2025 in “ Journal of Skin and Stem Cell ”
    Mohammed Abu El-Hamd, Moustafa Adam El-Taieb, Faten Othman Ahmed, Ali Mohamed Younis, Mohamed Amer Ahmed Abdellatif, Eisa M. Hegazy
    Image of study
    TLDR The combination of calcipotriol and PRP is the most effective treatment for alopecia areata.
    This study evaluated the effectiveness of topical calcipotriol, intralesional autologous platelet-rich plasma (PRP) injection, and their combination in treating alopecia areata (AA) in 78 patients. Results showed significant reductions in the Severity of Alopecia Tool (SALT) scores across all treatment groups, with the combination treatment showing the greatest improvement (18.98 points), followed by the PRP group (6.87 points), and the calcipotriol group (3.73 points). The study concluded that all treatments were effective, with the combination therapy being the most effective.
    Discuss this study in the Community →

    Research cited in this study

    23 / 23 results

    Related Community Posts Join

    6 / 15 results

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 5 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  6 upvotes 3 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

      in Research/Science  54 upvotes 2 days ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Oral dut 0.5mg and oral minoxidil 5mg

      in Finasteride/Dutasteride  4 upvotes 3 days ago
      The user is using oral dutasteride, oral minoxidil, topical minoxidil, finasteride solution, tazarotene, calcipotriol, and a peptide serum for hair loss but is concerned about continued hair shedding. They are advised to stop smoking as it may worsen hair loss and to give the treatments more time to work.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  49 upvotes 11 months ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  412 upvotes 11 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

    Similar Research

    5 / 617 results