TLDR DNA microarrays help study skin diseases and biology, leading to advancements in understanding and treatment.
The document discussed the use of DNA microarrays in dermatology and skin biology, highlighting their application in studying skin cancers, psoriasis, and epidermal keratinocytes. It noted that skin was one of the first organs analyzed due to its accessibility, and DNA microarrays were used to investigate the transcriptional mechanisms regulating epidermal differentiation and cornification. The research also identified genes specifically expressed in epidermal stem cells. Artificial skin substitutes were used to study the effects of harmful agents due to ethical considerations. The document emphasized that skin research using DNA microarrays covered various aspects, including stem cells, differentiation, signaling, inflammation, diseases, and cancer, and anticipated continued advancements in the field.
550 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
27 citations,
August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Researchers found new genes involved in hair growth, which could help develop new hair treatments.
47 citations,
July 2004 in “Journal of Dermatological Science” Hair loss in balding individuals is linked to changes in specific hair growth-related genes.
99 citations,
January 2004 in “Journal of Biological Chemistry” Methylprednisolone helps skin cells stick together better in pemphigus vulgaris.
182 citations,
May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.
October 2007 in “Journal of Investigative Dermatology” The document suggests a bacteria plays a significant role in acne rosacea and that white hair can regain color after transplant, meriting more research on reversing grey hair.
3 citations,
September 2005 in “Experimental dermatology” The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.
October 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Mice treatments didn't grow hair, a patient treatment may affect immune response, and people with hair loss often feel anxious or depressed.
11 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
41 citations,
September 2012 in “Cellular and Molecular Life Sciences” MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.
