Diet and the Dermal White Adipose Tissue: Analyzing Shifts in the Cutaneous Lipid Landscape in Response to Dietary Change
dermal white adipose tissue dWAT lipid composition monounsaturated triacylglycerols TAGs polyunsaturated triacylglycerols saturated triacylglycerols omega-3 fatty acids alpha-linolenic acid ALA eicosapentaenoic acid EPA docosahexaenoic acid DHA skin health hair growth skin fat monounsaturated fats polyunsaturated fats saturated fats omega-3s
TLDR Different diets change the fat composition in mouse skin, often reducing beneficial omega-3 fatty acids.
The study investigated how different diets affect the lipid composition of dermal white adipose tissue (dWAT) in mice, which is important for skin health. Four groups of mice were fed different diets: a standard diet, a ketogenic diet, a western diet, and a steatohepatitis (NASH) diet. The lipid analysis revealed that, compared to the standard diet, the experimental diets led to an increase in monounsaturated triacylglycerols (TAGs) and a decrease in polyunsaturated TAGs in the dWAT. Mice on the ketogenic and western diets had increased saturated TAGs, while those on the NASH diet had decreased saturated TAGs. All three experimental diet groups showed significant decreases in essential omega-3 fatty acids in the skin, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), which are known to support skin health and hair growth. Further research is needed to understand how these dietary-induced changes in dWAT lipid composition impact skin function and disease.
