Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts
March 2022
in “Journal of Biomedical Science”
TLDR Cyanidin 3-O-arabinoside may help treat a common form of hair loss by protecting cells against aging and improving cell function.
The study investigated the effects of cyanidin 3-O-arabinoside (C3A) on dihydrotestosterone (DHT)-induced dermal papilla cell (DPC) senescence, a condition linked to androgenetic alopecia (AGA), a common form of hair loss. The researchers found that C3A decreased DHT-induced mitochondrial reactive oxygen species accumulation in DPCs and reversed DHT-induced DPC senescence. C3A also prevented excessive mitochondrial calcium accumulation and inhibited p38-mediated voltage-dependent anion channel 1 (VDAC1) expression, which contributes to mitochondria-associated ER membrane (MAM) formation and calcium transfer. In AGA mice models, C3A restored DHT-induced hair growth deceleration and activated hair follicle stem cell proliferation. The study concludes that C3A is a promising natural compound for AGA treatments against DHT-induced DPC senescence by reducing MAM formation and mitochondrial dysfunction.
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