The Collision Regions Between Two Epidemic Models: SIR vs. SEIR

January 2012

Yongqing Yuan

pediatric androgenetic alopecia trichoscopy hyperandrogenism topical minoxidil oral minoxidil topical finasteride hair transplants Rogaine Propecia

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This review discusses current knowledge on pediatric androgenetic alopecia and reports no new clinical results, highlighting the potential usefulness of topical and oral minoxidil, and topical finasteride. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviewed the state of evidence concerning pediatric androgenetic alopecia, highlighting it as an underrecognized disorder. It emphasized the importance of clinical evaluation with trichoscopy in children and adolescents experiencing hair loss or reduced hair density. Diagnosis was primarily clinical, involving observation of hair loss patterns and trichoscopy, with hyperandrogenism being excluded in some cases. Although no approved therapies existed for pediatric androgenetic alopecia, topical and oral minoxidil, as well as topical finasteride, were considered potentially useful. Hair transplants were suggested as an option for girls in selected cases.

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Research cited in this study

16 / 16 results

research Low-Dose Oral Minoxidil for Treatment of Androgenetic Alopecia and Telogen Effluvium in a Pediatric Population: A Descriptive Study

6 citations , April 2022 in “Journal of The American Academy of Dermatology”

In this study, low-dose oral minoxidil was found to improve hair density in 80% of pediatric patients with androgenetic alopecia or telogen effluvium, with mild side effects primarily reported.

research Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial

11 citations , October 2021 in “Journal of The European Academy of Dermatology and Venereology”

This study found that topical finasteride significantly increased hair count in men with androgenetic alopecia compared to placebo while maintaining similar efficacy to oral finasteride but with lower systemic exposure and a reduced impact on serum DHT levels, potentially minimizing sexual side effects.

research Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients

39 citations , February 2021 in “Journal of The American Academy of Dermatology”

In this study, low-dose oral minoxidil for hair loss was associated with infrequent systemic adverse effects, and only 1.7% of patients discontinued treatment due to these effects.

research Combination Oral Minoxidil and Spironolactone for the Treatment of Androgenetic Alopecia in Adolescent Girls

5 citations , December 2020 in “Journal of The American Academy of Dermatology”

This study observed objective improvement in androgenetic alopecia in 5 out of 6 adolescent girls treated with 2.5 mg oral minoxidil and spironolactone, and reported no adverse effects.

research Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride

40 citations , November 2020 in “JAMA Dermatology”

This pharmacovigilance study found an increased association of suicidality and psychological adverse events with finasteride use, especially among younger patients using it for alopecia.

research Efficacy and Safety of Oral Minoxidil in Female Androgenetic Alopecia

14 citations , September 2020 in “Dermatologic Therapy”

This study reported that oral minoxidil improved hair density and had an acceptable safety profile in women with androgenetic alopecia.

research Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies

15 citations , June 2020 in “Experimental Dermatology”

This review discusses recent genetic findings on hormonal signaling pathways in androgenetic alopecia, reporting no new study results but highlighting the need for further investigation.

research Spironolactone for Treatment of Female Pattern Hair Loss

15 citations , April 2020 in “Journal of The American Academy of Dermatology”

This article notes the lack of physician-reported outcome studies supporting the efficacy of off-label spironolactone in treating female pattern hair loss, despite its common prescription alongside FDA-approved topical minoxidil.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , November 2019 in “American Journal of Clinical Dermatology”

This review discusses female androgenetic alopecia, highlighting its diagnostic challenges and management strategies, but it reports no new results.

research The Diagnosis of Androgenetic Alopecia in Children: Considerations of Pathophysiological Plausibility

7 citations , June 2019 in “Australasian Journal of Dermatology”

This review discusses the role of androgen hormones in the pathophysiology of childhood androgenetic alopecia and reports no clinical results.

research Effectiveness and Safety of Low-Dose Oral Minoxidil in Male Androgenetic Alopecia

52 citations , May 2019 in “Journal of The American Academy of Dermatology”

This study evaluated the effectiveness and safety of low-dose oral minoxidil (2.5-5 mg daily) in men with male androgenetic alopecia, aiming to contribute data to an area with limited previous reports. Results are not provided in the abstract.

research Trichoscopy Features of Trichotillomania

29 citations , February 2019 in “Pediatric dermatology”

This abstract suggests that specific trichoscopic features like black dots, coiled hair, and trichoptilosis may help differentiate trichotillomania from patchy alopecia areata.

research Braids or Ponytail-Associated Traction Alopecia in Female Children

4 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

Changing hairstyles can help hair regrow in children with hair loss from tight braids or ponytails.

research Trichoscopy of Alopecia Areata: An Update

89 citations , March 2018 in “The Journal of Dermatology”

This review presents various trichoscopic findings for diagnosing alopecia areata but reports no new clinical results, emphasizing that no single marker is pathognomonic and multiple features should be considered together.

research Infantile Generalized Hypertrichosis Caused by Topical Minoxidil

10 citations , February 2016 in “Anais Brasileiros de Dermatologia”

This case report describes a 5-year-old child in Brazil who developed generalized hypertrichosis after using topical minoxidil, suggesting caution when using it in children.

research Androgenetic Alopecia in the Pediatric Population: A Retrospective Review of 57 Patients

53 citations , March 2010 in “British Journal of Dermatology”

This study found that androgenetic alopecia is the leading cause of hair loss in adolescents and may indicate endocrine disorders, emphasizing the need for accurate diagnosis.