Using Qualitative Methods to Establish the Clinically Meaningful Threshold for Treatment Success in Alopecia Areata

    July 2022 in “ Quality of Life Research ”
    Kathleen W. Wyrwich, Helen Kitchen, S.L. Knight … Brett King
    Studysummary This study found that achieving 80% scalp hair regrowth (SALT score ≤ 20) is considered a meaningful treatment success by expert clinicians-then-patients with ≥ 50% scalp hair loss.
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    Research cited in this study 11

    1. Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan Dermatology and therapy · 2021
    2. The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms Journal of Investigative Dermatology Symposium Proceedings · 2020
    3. ‘You Lose Your Hair, What’s the Big Deal?’ I Was So Embarrassed, I Was So Self-Conscious, I Was So Depressed: A Qualitative Interview Study to Understand the Psychosocial Burden of Alopecia Areata Journal of Patient-Reported Outcomes · 2020
    4. Development of Clinician-Reported Outcome and Patient-Reported Outcome Measures for Eyebrow, Eyelash, and Nail Assessment in Alopecia Areata American Journal of Clinical Dermatology · 2020
    5. The Alopecia Areata Investigator Global Assessment Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials British Journal of Dermatology · 2020
    6. Review of Quality of Life Studies in Women with Alopecia International Journal of Women's Dermatology · 2018
    7. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    8. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    9. Health-Related Quality of Life Among Patients With Alopecia Areata: A Systematic Review Journal of The American Academy of Dermatology · 2016
    10. Alopecia Areata and Health-Related Quality of Life: A Systematic Review and Meta-Analysis British Journal of Dermatology · 2016
    11. Investigative Guidelines for Alopecia Areata Dermatologic therapy · 2011

    Related research 6

    1. Hydroxychloroquine for Granuloma Annulare: A Case Report on Secondary Hair Growth in Alopecia Universalis SAGE Open Medical Case Reports · 2023
    2. Using Qualitative Methods to Establish the Clinically Meaningful Threshold for Treatment Success in Alopecia Areata Quality of Life Research · 2022
    3. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    4. Topical and Intralesional Therapies for Alopecia Areata Dermatologic therapy · 2011
    5. Turban PUVASOL: An Effective Treatment in Alopecia Totalis International journal of trichology · 2010
    6. Alopecia Areata: Evidence-Based Treatments Seminars in cutaneous medicine and surgery · 2009