Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan

January 2021 in “ Dermatology and therapy ”

Jake Macey, Helen Kitchen, Natalie V. J. Aldhouse, Russel Burge, Emily Edson-Heredia, Jill Shwed McCollam, Yoshitaka Isaka, Hitoe Torisu‐Itakura

alopecia areata scalp hair loss AA-IGA Scalp Hair Assessment PRO clinical outcome assessments AA COAs

TLDR Both dermatologists and patients in Japan agree that treatment success for alopecia areata is having 20% or less scalp hair loss.

This study confirmed the content validity and treatment success thresholds of clinical outcome assessments (COAs) for alopecia areata (AA) in Japan, aligning with findings from North America. Interviews with 7 dermatologists and 15 patients with ≥ 50% scalp hair loss revealed that both groups prioritized scalp hair loss over other symptoms and agreed that achieving ≤ 20% scalp hair loss indicated treatment success. The AA-IGA™, Scalp Hair Assessment PRO™, and other COAs were deemed appropriate and clinically meaningful for measuring AA symptoms. These results support the use of these measures in AA treatment studies.

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